Objective To explore the clinical effect of Bugan Qiangshen Zhuanggu Formula in treating primary osteopo-rosis(liver and kidney deficiency type).Methods A total of 130 patients with primary osteoporosis(liver and kidney deficiency type)admitted to Tiantai County People's Hospital from April 2020 to October 2023 were studied,and were divided into control group(65 cases)and observation group(65 cases)randomly.The control group were given alendr-onate sodium tablets and calcium carbonate D3 tablets,while the observation group received additional treatment with Bugan Qiangshen Zhuanggu Formula.The therapeutic effect level of traditional Chinese medicine syndrome in patients were evaluated,the changes in bone density and serum bone metabolism indicators were detected,the differences in VAS score and SF-36 score were compared,and the adverse drug reactions were observed.Results The overall effective rate of traditional Chinese medicine syndromes in observation group(93.85％,61/65)was higher than control group(69.23％,45/65,P＜0.001).After 12 weeks of treatment,the bone density values of the lumbar spine L2_4,right fem-oral neck,and left distal radius in the observation group were higher than the control group(P＜0.001).The VAS score of observation group(2.47±0.63)was lower than control group(3.29±0.72,P＜0.001),while the SF-36 score(85.73±6.49)was higher than control group(74.65±6.27,P＜0.001).The levels of serum bone-specific alkaline phosphatase(BALP)and type Ⅰ procollagen amino terminal peptide(P1NP)in observation group was higher than con-trol group,but the levels of serum cross-linked type 1 collagen C-terminal peptide(CTX)and N-telopeptide of type Ⅰcollagen(NTX)were lower than control group(P＜0.001).The incidence of adverse reactions between the two groups was no difference(P＞0.05).Conclusion Bugan Qiangshen Zhuanggu Formula combined with alendronate sodium and calcium carbonate D3 can effectively improve traditional Chinese medicine symptoms,alleviate pain reactions,and im-prove quality of life in patients with primary osteoporosis of liver and kidney deficiency type.Its mechanism of action is closely related to enhancing patient bone density and regulating bone metabolism function.
维普
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