Neonatal brain injury is a common neurological disorder in the newborn period,often associated with various factors such as perinatal asphyxia,hypoxic-ischemic events,hyperbilirubinemia,prematurity,and infections.The prog-nosis can range from early neurobehavioral abnormalities to various degrees of long-term neurodevelopmental disorders.Therefore,early and accurate identification of neonatal brain injury and timely intervention are crucial in preventing ad-verse neurodevelopmental outcomes.Brainwave monitoring is an important tool for diagnosing,evaluating,and predicting the prognosis of neonatal brain diseases.In recent years,amplitude-integrated electroencephalography(aEEG)as a non-invasive brain function monitoring tool has gradually been used in neonatal intensive care units.Compared to traditional e-lectroencephalography,aEEG signal processing is simplified,focusing mainly on low-frequency waveforms in the spec-trum.Its output typically displays as a continuous trend graph,making it easy for clinicians to observe and analyze.Therefore,aEEG is currently widely used for early brain function monitoring in neonatal brain injuries caused by birth as-phyxia,hypoxic-ischemic encephalopathy,neonatal hyperbilirubinemia,neonatal seizures,and neonatal infections.Since aEEG can be initiated within a few hours after birth,it can promptly detect abnormal brainwave activity,demonstrating high sensitivity and specificity in the early diagnosis,evaluation,and prognosis prediction of neonatal brain injuries.With further research into aEEG in neonatal clinical settings,continuous improvement of aEEG technology,establishment of standardized aEEG monitoring procedures,and the integration of other brain structure or function assessment tools,will effectively enhance the diagnostic and prognostic value of neonatal brain injuries,enabling early detection of brain injuries and developmental abnormalities,and thereby improving outcomes through early intervention.
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