Objective In order to improve the clinical treatment level of internal hemorrhoids and explore a scientifically effective combination of traditional Chinese and Western medicine treatment approach,this study explores the clinical effect and pharmacological mechanism of Bianxue Formula to improve clinical symptoms in patients with internal hemor-rhoids.Methods A total of 150 patients with grade Ⅰ and Ⅱ internal hemorrhoids admitted to the Department of Ano-rectal of Jiaxing Hospital of Traditional Chinese Medicine from January 2020 to December 2023 were selected as the re-search objects.According to the random number table method,they were divided into the control group(75 cases)and the observation group(75 cases).The control group was treated with compound cabbage ester suppository,while the ob-servation group was treated with an additional formula for constipation and bleeding on the basis of compound carrageenan suppositories.The improvement of clinical symptoms such as rectal bleeding,pain,and hemorrhoid mucosal status before and after treatment were observed,the level of clinical efficacy was evaluated,the changes in serum vascular endothelial factor and inflammatory factor levels were detected,and the adverse drug reactions during treatment were followed up.Results After treatment,the observation group had lower scores for rectal bleeding,falling pain,and hemorrhoid muco-sal status compared to the control group(P＜0.001).The overall effective rate of hemorrhoid treatment in the observation group[93.33％(70/75)]was higher than the control group[74.67％(56/75),P＜0.05].The levels of vascular en-dothelial factors in serum such as endothelin 1(EF-1),intercellular adhesion factor-1(ICAM-1),vascular cell adhesion factor-1(VCAM-1),and endothelial nitric oxide synthase(eNOS)in the observation group after treatment was lower than the control group(P＜0.001).The content of inflammatory factors in serum such as IL-1β,IL-6,IL-8,and TNF-α in the observation group after treatment were lower than the control group(P＜0.001).Conclusion The combi-nation of Bianxue Formula and compound cabbage ester suppository can effectively alleviate clinical symptoms in patients with internal hemorrhoids,improve clinical efficacy,and the improvement of clinical symptoms is closely related to the pharmacological mechanism of Bianxue Formula in inhibiting vascular endothelial injury and inflammatory response.
维普
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