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社区视角下老年人群高尿酸血症与慢性代谢性疾病的相关性分析

Correlation analysis between hyperuricemia and chronic metabolic diseases in the elderly population from the community perspective

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目的 分析社区老年人群高尿酸血症(HUA)患病现状,探讨HUA界值及血尿酸水平与慢性代谢性疾病的相关性.方法 该研究为横断面研究,以2023年上海闵行区2个社区参与体检的1 508例老年人为研究对象.主要观察指标为血清尿酸、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血脂检测、身高、体重、腰围、血压等.HUA定义为血清尿酸男性>420 µmol/L,女性>360 µmol/L.结果 该人群HUA总体粗患病率为26.8%(404/1 508,95%CI:24.6%~29.1%),男性为24.7%(182/736),女性为28.8%(222/772).男女性患病率均随年龄增长呈上升趋势,并且HUA组慢性代谢性疾病患病率均显著高于非HUA组.女性HUA患者不同尿酸水平合并慢性代谢性疾病比例差异无统计学意义.多因素回归分析显示,高血压(OR男=1.847,95%CI:1.209~2.820;OR女=1.519,95%CI:1.009~2.288)、高 TG(OR男=1.296,95%CI:1.100~1.527;OR女=1.619,95%CI:1.316~1.991)是HUA的危险因素,BMI与尿酸水平呈正相关关系.结论 社区老年人群HUA患病率较高.高血压、高TG是HUA的危险因素.血尿酸>360 µmol/L的女性均合并较高比例的慢性代谢性疾病,建议女性血尿酸控制目标水平<360 μmol/L.
Objective To analyze the current status of hyperuricemia(HUA)in the elderly population in the communi-ty,explore the critical value of HUA,and the correlation between serum uric acid levels and chronic metabolic diseases.Methods A cross-sectional study was conducted on 1 508 elderly individuals who participated in physical examinations in two communities in Minhang District,Shanghai in 2023.The main outcome measures were serum uric acid,fasting plasma glucose(FPG),glycated haemoglobin(HbAlc),and blood lipid detection.Height,weight,waist circumfer-ence,and blood pressure were also measured.HUA was defined as serum uric acid>420 µmol/L in males and>360 µmol/L in females.Results The estimated prevalence in this population was 26.8%(404/1 508,95%CI:24.6%-29.1%)overall,24.7%(182/736)in males and 28.8%(222/772)in females.The prevalence of males and females increased with age,and the incidence of chronic metabolic diseases in HUA groups was significantly higher than those in non-HUA groups.There was no statistically significant difference in the proportion of chronic metabolic diseases among females with different serum uric acid levels in HUA.Multivariate regression analysis showed that hypertension(ORmale=1.847,95%CI:1.209-2.820;ORfemale=1.519,95%CI:1.009-2.288),high values of TG(ORmale=1.296,95%CI:1.100-1.527;ORfemale=1.619,95%CI:1.316-1.991)were the strong risk factors for HUA,and BMI was positively correlated with uric acid levels.Conclusion The prevalence of HUA among the elderly population in the Com-munity is relatively high.Hypertension and high values of TG are strong risk factors for HUA.Females with serum uric acid>360 μmol/L are associated with a higher proportion of chronic metabolic diseases.It is recommended to control the target level of serum uric acid in Females to be less than 360 μmol/L.

HyperuricemiaThe agedChronic metabolic diseasesRelated factor

顾汝英、李娟、陈燕、王朝昕

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复旦大学上海医学院闵行区虹桥社区卫生服务中心,上海 201103

海南医学院管理学院,海南海口 570216

高尿酸血症 老年人 慢性代谢性疾病 相关因素

国家重点研发计划项目

2022YFC3601505

2024

中华全科医学
中华预防医学会,安徽省全科医学会

中华全科医学

CSTPCD
影响因子:1.688
ISSN:1674-4152
年,卷(期):2024.22(8)