Objective To investigate the relationship between preoperative systematic immune-inflammation index(SII),prognostic nutritional index(PNI),and platelet to lymphocyte ratio(PLR)and the prognosis of patients under-going radical cystoprostatectomy.Methods Clinical and pathological data of 179 bladder cancer patients who underwent radical cystectomy from January 2012 to December 2022 in the First Affiliated Hospital of Xinjiang Medical University and met the inclusion criteria were retrospectively analyzed.The optimal critical values of SII,PLR,and PNI before treat-ment were determined according to the ROC curve,the patients were divided into the high-level group and the low-level group.The Kaplan-Meier method was used to analyze the 3-and 5-year survival rates of the two groups,and univariate and multivariate Cox regressions were performed to analyze the prognostic risk factors of bladder cancer.Results The ar-ea under the ROC curve of SII,PNI,and PLR before treatment were 0.823,0.739,and 0.813,respectively,as deter-mined by the patient's overall survival.The results of the univariate analysis suggested that age,underlying disease,smoking history,T-stage,N-stage,whether the lymphatic vasculature was invaded,the number of tumours,whether the patients suffer from hydronephrosis,PLR,SII,and PNI were related to the OS of the patients(P＜0.05).Age,underly-ing disease,lymphovascular invasion,hydronephrosis,PLR,SII,and PNI were associated with the prognosis of patients with bladder cancer(P＜0.05).Conclusion Pre-treatment SII,PNI,and PLR are independent predictors of prognosis in patients with intermediate and advanced oesophageal cancer,and low SII,high PNI,and low PLR suggest a better prognosis.
Bladder cancerPrognosisSystematic immune-inflammation indexPrognostic nutritional indexPlatelet to lymphocyte ratio
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