Objective To analyze the correlation between the levels of IL-10 and IL-32 and the cognitive dysfunction and non-motor symptoms of Parkinson's disease(PD),we measured levels of IL-10 and IL-32 in the peripheral blood of Par-kinson's disease patients and healthy controls and evaluated their cognitive function and non-motor symptoms.Methods Sixty patients with Parkinson's disease in the First Affiliated Hospital of Bengbu Medical University from Jan-uary 2022 to October 2023 were selected as the observation group,and 60 healthy subjects were selected as the control group.Serum concentrations of IL-10 and IL-32 in the two groups were detected by ELISA.The cognitive function and non-motor symptoms of the two groups were evaluated using the simple mental state checklist and the motor symptom as-sessment scale.The correlation between peripheral inflammatory factors IL-10 and IL-32 and cognitive dysfunction and non-motor symptoms of Parkinson's disease was analyzed by hierarchical correlation method.Results The level of IL-10 in the peripheral blood of PD group was[136.60(117.05,169.70)pg/mL],which was higher than that of the control group[110.90(92.15,129.50)pg/mL,P＜0.01].The level of IL-32 in the PD group was[32.35(28.83,37.68)pg/mL],which was higher than that in the control group[21.80(20.60,23.35)pg/mL,P＜0.01].The level of IL-10 in the peripheral blood of PD patients was positively correlated with MMSE score(20.68±6.33)and NMSS score(103.17±11.25,P＜0.01).The level of IL-32 in the peripheral blood in PD patients was also positively correlated with MMSE score and NMSS score(P＜0.01).Conclusion The levels of inflammatory factors IL-10 and IL-32 in the pe-ripheral blood of PD patients were higher than those of healthy controls,and were closely correlated with cognitive dys-function and non-motor symptoms of PD.
维普
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