Objective To investigate the clinical efficacy of botulinum toxin type A in combination with laser on facial a-trophic acne scars.Methods Fifty patients with facial atrophic acne scars who visited the Department of Plastic and Burn,the First Affiliated Hospital of Bengbu Medical University from October 2021 to October 2022 were selected.Pa-tients were randomly divided into control group and observation group by random number method with 25 cases in each group.All patients received three laser treatments each,and dual-mode coverage was selected for laser treatment,with an interval of 8-10 weeks between each laser treatment.In observation group,an injection of botulinum toxin type A was given under the scar within 7-14 days after the first laser treatment.Before the treatment and three months after the end of the treatment,the efficacy of the patients'facial acne scars was comparatively analyzed using the echelle d'evaluation clinique des cicatrices d'acne(ECCA)weighting scale and the integrated visualization system(IVS),respectively,and the patients'satisfaction and adverse reactions were recorded.Results The ECCA score of observation group after treat-ment was 60.0(45.0,60.0)points,of which the mean rank was 21.96,and the ECCA score of control group after treatment was 60.0(60.0,60.0)points,of which the mean rank was 29.04,and the analysis of the data showed that the overall ECCA score of observation group after treatment was lower than that in control group,and the difference was statistically significant(Z=-2.014,P=0.044).The difference between the ECCA before and after treatment for the ob-servation group was 15.0(0.0,15.0),compared to 0.0(0.0,7.5)for the control group.The change in ECCA for the observation group was significantly higher than that of the control group,with statistical significance(Z=-2.076,P=0.038).The IVS score in observation group[3.0(2.0,3.0)points]was higher than that in control group[2.0(1.0,2.0)points],and the satisfaction score of the observation group[3.0(3.0,4.0)points]was higher than that in control group[2.0(2.0,3.0)points],and the differences were statistically significant(P＜0.05).Conclusion Botulinum toxin type A combined with exfoliative fractional laser is effective in the treatment of facial atrophic acne scar-ring and can inhibit the skin's oil secretion situation and intervene in the development of acne and its scarring to a certain extent,which is of clinical reference.
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