Objective High-dose opioid analgesics can control severe pain after thoracic surgery,but can easily cause nausea,respiratory depression,and other side effects.In this study,erector spinae plane block(ESPB)was applied to thoracic surgery before operation to explore its influence on postoperative stress and opioid demand of patients.Methods From March 2021 to March 2023,200 patients with lung cancer who underwent elective radical resection of lung cancer in the First People's Hospital of Linping District,Hangzhou were divided into a control group(pure intrave-nous anesthesia)and a compound group(ESPB combined intravenous general anesthesia)according to anesthesia meth-ods,with 100 patients in each group.The indexes of oxidative stress,serum-related indexes,pain,and opioid use were compared between the two groups.Results Malondialdehyde(MDA)levels increased and super oxide dismutase(SOD)levels decreased 24 h after operation in lung cancer patients in both groups.Moreover,MDA and SOD levels in the compound group[(6.69±1.84)nmol/L,(37.30±6.42)U/mL]were lower than those in the control group[(9.03±1.35)nmol/L,(41.56±6.88)U/mL,P＜0.05].At T1,T2,andT3,the levels of IL-6,Cor,and Ang-Ⅱin the compound group were lower than those in the control group,and the levels of IL-10 were higher than those in the control group(P＜0.05).At T2,T3,and T4,the scores of resting and dynamic VAS in the compound group were lower than those in the control group(P＜0.05).The dosage of remifentanil in the compound group was(554.8±97.2)µg.The total amount of sufentanil infusion[(28.7±5.9)mL]and the number of supplementary infusion[(2.1±0.6)times]in 24 h were lower than those in the control group[(675.2±164.5)µg,(39.5±6.2)mL,(3.2±0.9)times,P＜0.05].Conclusion The application of ESPB combined with intravenous general anesthesia in radical resection of lung cancer can improve stress and inflammatory reaction,and reduce postoperative pain and the demand for opioids.It is a feasible and superior anesthesia method.
Erector spinae plane blockSufentanilRadical operation of lung cancerInterleukin 6
维普
万方数据
