Acute type A aortic dissection(ATAAD)is a complex and extremely dangerous cardiovascular disease charac-terized by pathological changes of aortic anatomy,systemic inflammatory response,and coagulation dysfunction,which poses a serious threat to human life and health.Currently,risk factors such as advanced age,obesity,preoperative nerve injury,massive blood transfusion,operation time,poor tissue and organ perfusion,and hemodynamic damage caused by cardiac tamponade or poor coronary perfusion are considered to be independent predictors of death in patients with ATA-AD.However,these risk factors still do not meet the needs of clinical practice.In ATAAD cases,inflammation reaction and coagulation dysfunction often coexist,the complex interactions between coagulation and inflammation playing a role in the occurrence and development of ATAAD.Recent studies have shown that markers of coagulation and inflammation can aid in assessing the prognosis of ATAAD patients while enhancing predictive performance when incorporated into clinical prediction models(CPMs),surpassing traditional prediction models.Therefore,this article aims to review and summa-rize the relevance of systemic coagulation-inflammatory markers to the prognosis of ATAAD patients,as well as their role in establishing prediction models.This research progress provides novel insights for early clinical diagnosis,early risk stratification,and early clinical intervention.
关键词
急性A型主动脉夹层/预后/凝血/炎症/标志物/预测价值/临床预测模型
Key words
Acute type A aortic dissection/Prognosis/Coagulation/Inflammation/Biomarkers/Predictive value/Clini-cal prediction model
维普
万方数据