Objective This study aims to explore the potential causal relationship between type 2 diabetes mellitus(T2DM)and colorectal cancer(CRC)using a two-sample Mendelian randomization(MR)method.Methods Summa-ry data were obtained from genome-wide association studies(GWAS)datasets,including 490 089 cases for the exposure(T2DM)and 383 348 cases for the outcome(CRC).To minimize linkage disequilibrium and confounding factors,and to ensure strong association,47 single nucleotide polymorphisms(SNPs)were selected as instrumental variables(IVs)for the study.The inverse variance weighted(IVW)method was used as the primary analysis,with supplementary analysis by the weighted median method,MR-Egger method,simple mode method,and weighted mode method to assess the caus-al relationship.Sensitivity analysis was conducted using the leave-one-out method,and visual tools were employed to fur-ther evaluate the reliability and robustness of the MR results.Heterogeneity was assessed using Cochran's Q test for both the IVW method and MR-Egger method,while pleiotropy was evaluated using the MR-Egger intercept method.Results The IVW method indicated no significant causal relationship between T2DM and CRC(OR=1.000,95％CI:0.999-1.001,P=0.790).These results were consistent across the weighted median method(P=0.386),MR-Egger method(P=0.137),simple mode method(P=0.275),and weighted mode method(P=0.479).The leave-one-out analysis did not identify any individual SNPs that significantly influenced the overall results.Both heterogeneity tests(P＞0.05)and pleiotropy tests(P＞0.05)supported the reliability and robustness of the MR conclusions.Conclusion There is no evident genetic causal relationship between T2DM and colorectal cancer.
Type 2 diabetes mellitusColorectal cancerCausal relationshipMendelian randomization
维普
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