Objective In recent years,many studies have shown that many diseases are associated with apolipoprotein E(APOE)gene diversity.The aim of this study is to investigate the predictive value of the APOE gene in acute ischemic stroke(AIS)caused by intracranial vascular stenosis and its role in evaluating its prognosis.Methods A total of 511 patients with acute ischemic stroke admitted to the First Affiliated Hospital of the University of Science and Technology of China from January 2022 to December 2023 were collected.According to the presence or absence of intracranial artery stenosis,they were divided into the intracranial artery stenosis(ICAS)group(317 cases)and the non-intracranial artery stenosis(NCAS)group(194 cases).At the 6-month follow-up,According to whether they carried the APOE-e4 gene or not,they were further divided into e4 carrier group(213 cases)and non-e4 carrier group(298 cases).Variable such as age,gender,comorbidities,blood lipids,lipoprotein,apolipoprotein E(including allele typing),and lipoprotein A were analyzed,along with high-resolution magnetic resonance imaging of the vessel wall.Followed up evaluations were conduc-ted 6 months after the operation,with results tracked via high-definition vessel wall imaging.Results The plasma APOE concentration in the ICAS group was significantly lower than that in the non-intracranial artery stenosis group(r=0.481,P＜0.01).Among the e4 carriers,97/213(45.54％)had a poor prognosis,while 48/298(16.11％)of non-e4 carri-ers experienced poor prognosis at the end of treatment and after 6 months of follow-up,with a significant difference(OR=4.622,95％CI:3.512-6.091,P＜0.01).Conclusion Low plasma APOE levels are a risk factor for acute ischemic stroke caused by ICAS,and the APOE-e4 gene is associated with poor functional prognosis in AIS patients.Combining the APOE-e4 genotype with high-resolution vessel wall imaging may be valuable in predicting acute ischemic stroke and evaluating functional outcomes.
关键词
急性缺血性脑卒中/载脂蛋白E/血管壁高分辨率磁共振成像/功能评估/临床价值
Key words
Acute ischemic stroke/Apolipoprotein E/High resolution magnetic resonance imaging/Functional assess-ment/Clinical value
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