Objective Papillary thyroid carcinoma(PTC)is a common malignant tumor.The incidence rate is increasing year by year,and its pathogenesis and clinical characteristics are still not very clear.This article intends to explore the re-lationship between the BRAFV600E gene mutation detection results and the clinicopathological characteristics of PTC patients,so as to provide a basis for treatment decisions of PTC patients.Methods According to strict inclusion criteria,eligible case data were collected from patients with papillary thyroid carcinoma admitted to the First Affiliated Hospital of Bengbu Medical University from January 2022 to September 2022.Chi-square test and logistic analysis were used to analyze the BRAFV600E gene mutation and its relationship with clinical and pathological characteristics in PTC patients.All clinical data were statistically analyzed using SPSS 26.0 software.Results This study included 108 patients with papillary thyroid car-cinoma,with a BRAFV600E gene mutation rate of 70.37％(76/108).The results of univariate analysis showed that the pres-ence of Hashimoto's thyroiditis,central lymph node metastasis,capsule invasion,and maximum diameter of tumor ≥0.5 cm were associated with BRAFV600E gene mutations,and the difference was statistically significant(P＜0.05).The logistic analysis results showed that age ≥55 years and maximum diameter of tumor ≥0.5 cm were risk factors for BRAFV600E muta-tion,while Hashimoto's thyroiditis was a protective factor for BRAFV600E mutation.Conclusion BRAFV600E detection has a certain diagnostic value in papillary thyroid carcinoma.The results of BRAFV600E detection are correlated with some clinical and pathological features of papillary thyroid carcinoma.The results of BRAFV600E detection have good guiding significance for clinical treatment decision-making and prognosis judgment.
万方数据
