Objective To investigate the relationship between the changes of estrogen receptor(ER),progesterone re-ceptor(PR),human epidermal growth factor receptor 2(Her-2)and proliferation-associated antigen(Ki-67)in breast cancer patients before and after neoadjuvant chemotherapy(NAC).Methods The data of 100 patients with breast canc-er who received neoadjuvant chemotherapy in the First Affiliated Hospital of Bengbu Medical University from January 1,2020 to December 31,2021 were collected.Finally,80 patients were included in the study.The NAC regimen used an-thracycline combined with taxoid regimen,and the NAC regimen for Her-2 positive patients was docetaxel+carboplatin+trastuzumab+pertuzumab(TCbHP).After NAC,all patients underwent surgery for breast cancer.Immunohistochemical tests were performed on postoperative tumor residual samples,and the expression changes of related indicators were recor-ded.According to the grading of Miller-Payne system and postoperative pathological results,the patients were divided in-to pathologically complete response group(pCR)and non-pathologically complete response group(non-pCR).X2 test and multiple logistic regression model were used to analyze the differences in the expression of ER,PR,Her-2 and Ki-67 before and after chemotherapy in the non-PCR group,and to analyze whether the expression changes of these molecules were correlated with the disease control rate of patients.Results The change rates of ER,PR,Her-2 and Ki-67 before and after NAC were 2.50％,7.50％,10.00％and 40.00％,respectively.There were statistically significant differences in the expression changes of Ki-67(P=0.011)before and after NAC,while there were no statistically significant differ-ences in the expression changes of ER(P=0.737),PR(P=0.581)and Her-2(P=0.108).In addition,multiple lo-gistic regression analysis showed that Ki-67 high expression was an independent predictor of clinical disease control rate of neoadjuvant chemotherapy(P＜0.05).Conclusion NAC treatment may affect Ki-67 expression,while ER,PR and Her-2 do not change significantly.Patients with reduced Ki-67 expression levels after NAC may have a higher rate of dis-ease control.
维普
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