Objective This study aimed to investigate the correlation between blood glucose fluctuations,interleukin-6(IL-6),and serum tumor necrosis factor-alpha(TNF-α)levels following CO2 laser and imiquimod treatment(CO2-Ⅰ)in patients with diabetes mellitus complicated by anogenital(DMCA),and their association with recurrence rates.Methods A prospective cohort study was conducted on 136 DMCA patients treated with CO2-Ⅰ at the People's Hospital of Bozhou,from August 2020 to December 2022.Post-treatment,all patients underwent continuous blood glucose monito-ring for 72 hours to calculate the mean amplitude of glycemic excursion(MAGE).After discharge,patients were followed up for six months to evaluate short-term recurrence.Patients were divided into a recurrence group and a non-recurrence group based on their post-treatment recurrence status.The impact of blood glucose fluctuations on short-term recurrence in diabetic patients with condyloma acuminatum(DMCA)following CO2 laser treatment(CO2-Ⅰ)was analyzed.Results Among the 136 DMCA patients,34(25.00％)experienced recurrence,while 102(75.00％)did not.The recurrence group exhibited significantly higher levels of MAGE,IL-6,and TNF-α compared to the non-recurrence group,with these differences being statistically significant(P＜0.05).Multivariate logistic regression analysis indicated that higher MAGE values(≥3.9 mmol/L,OR=1.527,P＜0.001),higher incidence of anorectal and/or genital erosion(OR=2.786,P=0.016),elevated TNF-α levels(≥6.39 μg/L,OR=1.746,P=0.001),and decreased IL-6 levels(＜5.26 pg/mL,OR=1.725,P=0.001)were risk factors for the recurrence.Conclusion In DMCA patients treated with CO2-Ⅰ,high MAGE values,increased expression of TNF-α and lower IL-6,and the presence of anorectal and/or genital erosion significantly increase the risk of short-term recurrence.These findings hold certain clinical implications and may provide a basis for prognosis assessment.
AcromegalyDiabetes mellitusCO2 laser and imiquimod treatmentBlood glucose fluctuationRecurrence
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