Significance of nutritional status evaluation of BMI combined with hematological indexes in chemotherapy tolerance of patients with advanced digestive tract tumor after operation
Significance of nutritional status evaluation of BMI combined with hematological indexes in chemotherapy tolerance of patients with advanced digestive tract tumor after operation
Objective The nutritional status of patients with advanced digestive tract tumours has been demonstrated to affect their tolerance to chemotherapy.Consequently,an accurate evaluation of the nutritional status of patients with ad-vanced digestive tract tumours is conducive to the early identification of high-risk groups with chemotherapy intolerance of advanced digestive tract tumours.Accordingly,the evaluation of nutritional status included the measurement of BMI and hematological indices,with a view to analyzing their value in identifying chemotherapy tolerance in patients with advanced digestive tract tumours was analyzed.Methods A total of 255 patients with advanced digestive tract tumours who re-ceived chemotherapy at Lishui Central Hospital from August 2021 to January 2023 were divided into a tolerance group and an intolerance group according to their chemotherapy tolerance.Logistic regression was employed to analyze the factors in-fluencing the chemotherapy tolerance of patients with advanced digestive tract tumours,and the receiver operating charac-teristic(ROC)was constructed to analyze the value of nutritional evaluation of BMI combined with hematological nutri-tional indicators in predicting chemotherapy tolerance.Results A total of 255 patients with advanced digestive tract tumours were included in the study.Of these,58 patients were intolerant to chemotherapy,while 197 patients were also intolerant to chemotherapy.The results of the logistic regression analysis indicated that age(OR=1.098),BMI(OR=0.550),ALB(OR=0.593),PAB(OR=0.885)and TRF(OR=0.779)were the influencing factors of postoperative chemotherapy tolerance in patients with advanced digestive tract tumours(P＜0.05).Following age adjustment,BMI,ALB,PAB and TRF remain significant influencing factors of chemotherapy tolerance in patients with advanced digestive tract tumours(P＜0.05).The combined use of BMI,ALB,PAB and TRF yielded a C-index of 0.952 for predicting chemotherapy tolerance in patients with advanced digestive tract tumours.Conclusion The combination of BMI with he-matological nutritional indexes ALB,PAB and TRF can be employed to predict the chemotherapy tolerance of patients with advanced digestive tract tumours following surgical intervention.
关键词
晚期消化道肿瘤/体重指数/血液学指标/营养状态/化疗耐受性
Key words
Advanced digestive tract tumor/Body mass index/Hematology index/Nutritional status/Chemotherapy tol-erance
维普
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