Changes in inflammatory factors in children with allergic rhinitis before and after allergen-specific immunotherapy:expression spectrum and clinical significance
Objective To detect the expression levels of inflammatory factors in children with allergic rhinitis before and after subcutaneous specific immunotherapy(SCIT)and to analyze the application value of these inflammatory factors in e-valuating the efficacy of SCIT.Methods Eighty children with allergic rhinitis(AR)who received standard SCIT at the pediatric department of Chun'an Branch of Zhejiang Provincial People's Hospital from February 2021 to July 2023 were divided into a response group(n=48)and a non-response group(n=32)according to the curative effect.The baseline levels of inflammatory factors were compared between the two groups.The variables with P＜0.05 were selected for univa-riate logistic regression model,and the ROC curves were drawn to analyze the predictive effect of SCIT on AR children.Results After treatment,the levels of C-reactive protein(CRP),interleukin(IL)-lβ,IL-6,and IL-13 decreased,while the levels of tumor necrosis factor-β(TNF-β),IL-10,and IL-33 increased(P＜0.05).The baseline levels of IL-10 and IL-33 in children in the response group were lower than those in the non-response group(P＜0.05).Univariate logistic regression analysis showed that IL-10(OR=0.344)and IL-33(OR=0.963)significantly affected SCIT out-comes(P＜0.05).ROC curve showed that IL-10(AUC=0.836)and IL-33(AUC=0.833)have good predictive value for SCIT efficacy.Conclusion After SCIT treatment,the levels of TNF-β,IL-10,and IL-33 increased,while the levels of CRP,IL-1β,IL-6,and IL-13 decreased.Baseline levels of IL-10 and IL-33 are valuable predictors of efficacy.
Allergic rhinitisSubcutaneous specific immunotherapyInflammatory factorsChildren
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