Objective To analyze the characteristics of intestinal flora and the level of its metabolites in patients with ma-jor depressive disorder(MDD),and to explore its relationship with inflammatory factors.Methods A total of 98 MDD patients who were treated in Shaoxing Seventh People's Hospital from May 2020 to May 2023 were selected as the re-search object and 50 healthy people who received health examination in the same period were selected as the control group.The levels of intestinal flora metabolites and inflammatory factors between MDD patients and healthy people were compared,and the relationship between intestinal flora metabolites and inflammatory factors was analyzed by Pearson cor-relation.Results The levels of IL-1 β[(55.48±12.08)ng/L]and other inflammatory factors in the MDD group were higher than those in the control group[(42.15±10.03)ng/L,t=7.124,P＜0.001].The trimetlylamine oxide(TMAO)level in the MDD group[(3.25±0.71)μmol/L]was higher than that in the control group[(1.37±0.24)μmol/L,t=23.694,P＜0.001].The total amount of short chain fatty acids(SCFAs)in the MDD group[(18.26±2.94)μg/g]was lower than that in the control group[(22.03±3.25)μg/g,t=6.889,P＜0.001].In the MDD group,the TMAO level was positively correlated with the level of IL-1 β(r=0.404),IL-6(r=0.503),and CRP(r=0.454),and negatively correlated with TNF-αlevel(r=-0.348).The levels of SCFAs and IL-1β(r=-0.478),IL-6(r=-0.378),and CRP(r=-0.416)were negatively correlated(P＜0.05).Conclusion The levels of TMAO and SCFAs in the intestinal flora of MDD patients are closely related to the levels of inflammatory factors,and restoring the balance of intestinal flora metabolites plays an important role in the treatment of MDD.
Major depressive disorderIntestinal floraMetabolites of floraInflammatory factorShort chain fatty acidsTrimetlylamine oxide
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