Objective To analyze the characteristics of prefrontal lobe proton MR spectroscopy(1H-MRS)in patients with first-episode depressive disorder and evaluate its diagnostic value.Methods From January 2021 to December 2022,40 patients with first-episode depressive disorder who met the criteria and exclusion criteria were randomly selected as the study group according to the medical record number in the Bengbu First People's Hospital,while 40 healthy per-sons were randomly selected in Bengbu First People's Hospital Physical Examination Center as the control group.The 1 H-MRS indexes of the subjects were collected by superconducting magnetic resonance imaging system.The general infor-mation of the study subjects was collected using a self-made general situation questionnaire.The collected data was organ-ized and entered into the database.The chi square test,independent sample t-test and construct ROC curve on the data were analyzed by SPSS 20.0.Results(1)There was no significant difference in the distribution of sex,education,marriage,only child status,or age between the study group and the control group(P＞0.05).(2)The value of N-ace-tyl-based aspartate acid(NAA)/creatine(Cr)(1.74±0.73)in the study group was significantly lower than that in the control group(2.03±0.48,P＜0.05),while there was no significant difference in choline complex(Cho)/Cr between the study group(1.07±0.53)and the control group(1.11±0.31,P＞0.05).(3)Using NAA/Cr value as the test vari-able,and the study group and control group as state variables(study group=1,control group=0),ROC curves were constructed.NAA/Cr value demonstrated a certain predictive effect for first-episode depressive disorder(AUC=0.664,P=0.012).Conclusion Patients with first-onset depression show significantly reduced NAA/Cr values and decreased neuronal function in the frontal lobe.NAA/Cr is a valuable objective indicator for diagnosing first-onset depression.
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