Objective Under the premise of immunochemotherapy treatment of advanced lung cancer,Sijunzi Decoction was added to explore the effect of advanced lung cancer on patients,quality of life,T cell subsets,peripheral blood image,health.To provide a basis for clinical improvement of the efficacy of advanced lung cancer,improve the quality of life of pa-tients.Methods A total of 100 patients with advanced lung cancer admitted to Qingdao Central Hospital from August 2022 to August 2023 were included and divided into the observation group(n=50,Sijunzi Decoction combined with immunoche-motherapy)and the control group(n=50,immunochemotherapy)by random number table method.The clinical efficacy,quality of life[using function assessment of cancer therapy-lung cancer(FACT-L4.0)],T lymphocyte subsets(CD3+,CD3+/CD4+,CD3+/CD8+),and peripheral blood parameters[white blood cells(WBC),albumin(ALB),hemoglobin(Hb),platelets(PLT)]were compared before and after treatment.Survival status,such as progression-free survival(PFS),overall survival(OS),and adverse reaction rate were analyzed.Results The two groups had no significant difference in overall effective rate after 12 weeks of treatment[52％(26/50)vs.44％(22/50),P＞0.05].After 12 weeks of treatment,physiological status,functional status,CD4+/CD8+,WBC,ALB,PLT were all higher in 2 groups than be-fore treatment.The level of CD4+in observation group was higher than before treatment,CD8+in observation group was lower than before treatment,and Hb in control group below pre-treatment(P＜0.01).After 12 weeks of treatment,the ob-servation group had higher levels of CD4+,CD4+/CD8+,WBC,ALB,Hb,and PLT,but lower CD8+compared to the con-trol group(F=6.047,18.539,10.934,2.218,7.415,6.260,5.895,P＜0.05).In terms of PFS,OS or grade 3-4 ad-verse reactions,the two groups had no significant differences(P＞0.05).Conclusion Sijunzi Decoction combined with immunochemotherapy significantly improves the immune function of patients with advanced lung cancer,reduces toxic and side effects,and improves the quality of life in patients with advanced lung cancer.
Lung cancerSijunzi DecoctionChemotherapyT lymphocytesQuality of life
NETL
NSTL
万方数据
