Objective The application of traditional Chinese medicine(TCM)emotion and decoction in lung cancer pa-tients with bone metastasis,and in-depth understanding of the role of TCM treatment in alleviating pain,improving quali-ty of life and psychological status of lung cancer patients with bone metastasis,to provide clinical evidence for patients Provide more targeted treatment options.Methods A total of 128 advanced lung cancer patients with bone metastasis,admitted to Hengshui Hospital of Traditional Chinese Medicine from August 2022 to August 2023,were included in the study.They were divided into the observation group(n=64,receiving traditional Chinese medicine emotional interven-tion combined with Shentong Zhuyu Decoction)and the control group(n=64,receiving standard care)according to ran-dom number table method.The analgesic effect,cancer-related fatigue(cancer fatigue scale,CFS),mental resilience(10-item mental resilience scale,CD-RISC10),quality of life(American lung cancer quality of life scale,FACT-L4.0),and pain-related factors(β endorphin,β-EP,substance P)were measured before and 4 weeks after interven-tion.Results After 4 weeks of intervention,the total remission rate of the observation group was significantly higher[92.19％(59 cases)vs.78.12％(50 cases),X2=5.006,P＜0.05].After 4 weeks of intervention,CFS and P in the observation group were significantly lower than before intervention,while β-EP were significantly higher(P＜0.05).Af-ter 4 weeks of intervention,CD-RISC and FACT-L4.0 in the observation group were higher than those before intervention(P＜0.01).Pre-intervention CFS,CD-RISC,FACT-L4.0,β-EP,and P had significant effects on the results after 4 weeks of intervention(P＜0.001).After 4 weeks of intervention,CFS and P in the observation group were lower than those in the control group,while CD-RISC,FACT-L4.0 and β-EP were higher.After adjusting the levels of CFS,CD-RISC,FACT-L4.0,β-EP,and P before intervention,the differences between the two groups were statistically significant(P＜0.01).Conclusion TCM emotional intervention combined with Shentong Zhuyu Decoction improves cancer pain,cancer-related fatigue,mental resilience,and quality of life in patients with advanced lung cancer and bone metastasis.The analgesic mechanism may be mediated through improvements β-EP and P levels.
Lung cancerTraditional Chinese medicine emotional interventionShentong Zhuyu DecoctionBone metas-tasisPainCancer-related fatigueMental resilience
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