Objective The relationship between eczema and depression has received much attention,yet the causal asso-ciation between the two is unclear.Therefore,Mendelian randomization(MR)was used to investigate whether there is a causal relationship between eczema and depression.Methods Genotypic data of eczema and depression were selected from the publicly available pooled dataset of the Genome-wide association study(GWAS),with eczema as the exposure factor and depression as the outcome variable.The selected samples were genotyped using MR,where the instrumental variables were genetic loci with a strong correlation with eczema disease.The odds ratio(OR)was used as an estimator,and the effect value β judged the direction of the association between the two.Heterogeneity test,sensitivity analysis,and horizontal multiple validity test were also performed.Results Inverse variance weighted method analysis showed a posi-tive correlation between eczema and the occurrence of depression and yielded an OR of 1.011,95％CI:1.001-1.022,P=0.037;weighted median regression analysis yielded similar results(OR=1.012,95％CI:1.001-1.023,P=0.029).Cochran's Q test showed significant heterogeneity of the results(P＜0.05),but the analysis of the random effects model yielded P=0.037 and β=0.011,which proved that there was a positive causal relationship.In addition,no horizontal pleiotropy was observed for the funnel plot and MR-Egger intercept.Conclusion The findings suggest a possible positive causal relationship between eczema and the occurrence of depression.
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