湿疹与抑郁症的孟德尔随机化研究
Mendelian randomization study of eczema and depression
徐小然 1杨子涵 2宁竟 1孙付童语 1谭曦3
作者信息
- 1. 北京中医药大学生命科学学院,北京 100029
- 2. 北京中医药大学管理学院
- 3. 北京中医药大学深圳医院,广东 深圳 518100
- 折叠
摘要
目的 湿疹与抑郁症之间的关系备受关注,然而二者之间的因果关联尚不明确.本研究采用孟德尔随机法(MR)研究湿疹与抑郁症之间是否存在因果关系.方法 在公开的全基因组关联研究(GWAS)的集合数据集中选出湿疹与抑郁症的基因型数据,湿疹为暴露因素,抑郁症为结局变量.样本量为40 835例.利用MR对所选样本进行基因型分析,其中工具变量为与湿疹疾病有强相关性的基因位点.采用比值比(OR)作为估计指标,效应值β判断两者之间的关联方向.同时进行异质性检验、敏感性分析以及水平多效性检验.结果 逆方差加权法分析结果显示,湿疹与抑郁发生之间呈正相关关系(OR=1.011,95％CI:1.001～1.022,P=0.037);加权中位数回归分析得到了相似结果(OR=1.012,95％CI:1.001～1.023,P=0.029).Cochran's Q 检验显示结果存在显著异质性(P＜0.05),但通过随机效应模型分析得到P=0.037且β=0.011,证明二者存在正向因果关系.此外,漏斗图和MR-Egger截距未观察到水平多效性.结论 研究结果表明,湿疹与抑郁发生之间可能存在正向因果关系.
Abstract
Objective The relationship between eczema and depression has received much attention,yet the causal asso-ciation between the two is unclear.Therefore,Mendelian randomization(MR)was used to investigate whether there is a causal relationship between eczema and depression.Methods Genotypic data of eczema and depression were selected from the publicly available pooled dataset of the Genome-wide association study(GWAS),with eczema as the exposure factor and depression as the outcome variable.The selected samples were genotyped using MR,where the instrumental variables were genetic loci with a strong correlation with eczema disease.The odds ratio(OR)was used as an estimator,and the effect value β judged the direction of the association between the two.Heterogeneity test,sensitivity analysis,and horizontal multiple validity test were also performed.Results Inverse variance weighted method analysis showed a posi-tive correlation between eczema and the occurrence of depression and yielded an OR of 1.011,95％CI:1.001-1.022,P=0.037;weighted median regression analysis yielded similar results(OR=1.012,95％CI:1.001-1.023,P=0.029).Cochran's Q test showed significant heterogeneity of the results(P＜0.05),but the analysis of the random effects model yielded P=0.037 and β=0.011,which proved that there was a positive causal relationship.In addition,no horizontal pleiotropy was observed for the funnel plot and MR-Egger intercept.Conclusion The findings suggest a possible positive causal relationship between eczema and the occurrence of depression.
关键词
湿疹/抑郁症/孟德尔随机化Key words
Eczema/Depression/Mendelian randomization引用本文复制引用
出版年
2024
NETL
NSTL
万方数据