系统性红斑狼疮与重症肌无力:一项双向孟德尔随机化研究
Systemic lupus erythematosus and myasthenia gravis:a bidirectional Mendelian randomization study
郑乾 1余彩遥 1李浩云 1冯占辉1
作者信息
- 1. 贵州医科大学附属医院神经内科,贵州贵阳 550001
- 折叠
摘要
目的 研究显示系统性红斑狼疮(SLE)与重症肌无力(MG)临床上可能同时发病.本研究旨在利用双向孟德尔随机化方法探讨SLE与MG之间的潜在因果关系,为临床防治提供依据.方法 从全基因关联研究(GWAS)的汇总数据库中分别提取SLE和MG密切相关的遗传位点作为工具变量,提取数据均来自欧洲样本.分别采用IVW、MR-Egger回归和WME的方法进行MR分析,以OR值和95％CI评价SLE与MG之间的因果关系;采用MR-Egger intercept法检测水平多效性,留一法进行敏感性分析.结果 SLE与MG的风险增高相关(OR=1.698,95％CI:1.329～2.171,P＜0.001);同样的 MG 与 SLE 的风险增高相关(OR=1.527,95％CI:1.248～1.869,P＜0.001).双向结果均不存在异质性,均无水平多效性,留一法敏感性分析结果稳定.结论 SLE和MG具有双向因果关系,SLE患者会增加MG的发病风险,MG同样会增加SLE的发病风险.
Abstract
Objective Studies have shown that systemic lupus erythematosus(SLE)and Myasthenia gravis(MG)may have concurrent onset clinically.This study aims to explore the potential causal relationship between SLE and MG using a bidirectional Mendelian randomization study to provide a basis for clinical prevention and treatment.Methods Genetic data closely related to SLE and MG were extracted from the summary database of genome-wide association studies(GWAS)as instrumental variables,and the extracted data were all from European samples.MR analysis was conducted using IVW,MR-Egger regression,and WME.The causal relationship between SLE and MG was evaluated by the OR value and 95％CI.The MR-Egger intercept method was used to detect horizontal pleiotropy,and the leave-one-out meth-od was used for sensitivity analysis.Results SLE was associated with an increased risk of MG(OR=1.698,95％CI:1.329-2.171,P＜0.001);similarly,MG was associated with an increased risk of SLE(OR=1.527,95％CI:1.248-1.869,P＜0.001).There was no heterogeneity in the two-way results and no horizontal pleiotropy.The sensitivity analy-sis results of the leave-one-out method were stable.Conclusion There is a bidirectional causal relationship between SLE and MG.SLE patients will increase the risk of MG onset,and MG will also increase the risk of SLE onset.
关键词
系统性红斑狼疮/重症肌无力/孟德尔随机化/因果关系Key words
Systemic lupus erythematosus/Myasthenia gravis/Mendelian randomization/Causality引用本文复制引用
出版年
2024
NETL
NSTL
万方数据