Objective To analyze the clinical characteristics of patients with primary Sjögren's syndrome(pSS)compli-cated with liver function and multi-system damage,and to explore the risk factors of liver function damage in pSS,so as to provide new basis for clinical diagnosis and treatment.Methods A total of 92 patients diagnosed with PSS and liver function damage admitted to the 920th Hospital of the Joint Logistics Support Force of PLA from January 2020 to October 2023 were selected as liver injury groups,and 92 patients with PSS patients who has no liver damage were selected as non-liver injury groups.The clinical data and auxiliary examination results of the two groups of patients were collated for comparison and analysis.Results The combination of liver damage and blood system involvement(56.5％,52/92),joint and bone involvement(54.3％,50/92),and thyroid involvement(23.9％,22/92)in patients with pSS is signifi-cantly higher than in patients with pSS,however,without liver damage[34.8％(32/92),32.6％(30/92),8.7％(8/92),P＜0.05].The proportion of patients with involvement of two or more systems in the liver injury group(73.9％,68/92)is also significantly higher than that in the non-liver injury group(55.4％,51/92,P＜0.05).The levels of CRP[6.45(2.83,17.10)mg/L]and WBC[6.28(4.37,9.51)×109/L]in the pSS liver lesion group were found to be significantly higher than those in the non-liver injury group[2.45(0.80,8.40)mg/L,5.31(4.14,6.74)×109/L,P＜0.05].The positive rates of ANA(84.8％,78/92)and anti-SSB(50.0％,46/92)in the pSS liver injury group were significantly higher than those in the pSS non-liver injury group[65.2％(60/92)and 28.3％(26/92),respectively,P＜0.05].The logistic regression analysis demonstrated that elevated CRP(OR=1.037,95％CI:1.003-1.071,P＜0.05)and elevated WBC(OR=1.325,95％CI:1.139-1.542,P＜O.01),multi-system involvement(OR=2.262,95％CI:1.039-4.925,P＜0.05)were risk factors for liver function damage in pSS patients.Conclusion Patients with pSS who also have impaired liver function are frequently accompanied by multiple system im-pairment.Elevated CRP and WBC levels,in conjunction with multi-system involvement,constitute risk factors for pSS-related liver dysfunction.
Sjögren's syndromeLiver function impairmentMultisystem damage
NETL
NSTL
万方数据
