Objective To analyze the differences in AD7c-NTP levels and cognitive function among patients with early-onset depression,late-onset depression,and healthy elderly individuals,providing insights for the clinical diagnosis of geriatric depression.Methods A total of 174 elderly patients with depression admitted to Wuhu Hospital,Beijing An'ding Hospital Affiliated to Capital Medical University from January 2022 to January 2024 were selected as the study objects.Based on the age of first onset,depression patients were categorized into the early onset group(EOD,n=105;first onset＜60 years)and the late onset group(LOD,n=69;≥60 years).A control group of seventy-five healthy eld-erly patients(NC,n=75)were selected from hospital check-ups and community hospital centers.Urinary AD7c-NTP levels of all subjects were detected by ELISA,and the cognitive function of each group was assessed by Montreal cognitive assessment scale(MoCA).AD7c-NTP values and cognitive function scores were compared across the EOD,LOD,and NC groups.Spearman correlation analysis was performed to evaluate the relationship between MoCA scores and urine AD7c-NTP values.Results Significant differences in cognitive function and AD7c-NTP levels were observed among the EOD,LOD,and NC groups(P＜0.01).The cognitive levels were negatively correlated with urine AD7c-NTP levels in all groups(P＜0.01).In addition,depression levels were not associated with AD7c-NTP in the EOD group(P=0.799)and were not associated with AD7c-NTP in the LOD group(P=0.635).Conclusion The AD7c-NTP levels are signifi-cantly increased in patients with late-onset depression,who also exhibit cognitive deficits in attention and executive func-tion.While AD7c-NTP levels were not associated with depression severity,they were negatively correlated with cognitive function.AD7c-NTP level can serve as a predictive biomarker for detecting cognitive changes in the elderly.
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