Objective Allergic conjunctivitis(AC)is a common ocular surface disease.Although single-drug treatment can alleviate symptoms,the efficacy is limited,and the recurrence rate is high.Therefore,exploring combination therapy strategies to optimize treatment plans is of great significance.The aim of this study is to investigate the efficacy and safety of Pralofen combined with Emadine in the treatment of AC,providing,reference for clinical treatment planning.Methods A total of 124 patients with AC admitted to the ophthalmology department of our hospital from October 2023 to June 2024 were randomly divided into Group A and Group B.Group A,consisting of 62 patients,was treated with Pralofen,while Group B,consisting of 62 patients,was treated with Pralofen combined with Emadine.The improvement of symptoms,tear film stability,tear index levels,inflammatory factor levels,clinical efficacy,and adverse reactions were observed in both groups.Results The scores of photophobia,tearing,eye itching,and eye secretions in group B were lower than those in group A after treatment(P＜0.05).The BUT of group B after treatment was longer than that of group A(P＜0.05),and the CFS score was lower than that of group A(P＜0.05).The ECP,HA,and LTB4 levels in group B were lower than those in group A after treatment(P＜0.05).The levels of IL-6,TNF-α,and hs-CRP in group B were lower than those in group A after treatment(P＜0.05).The total effective rate of Group B was 91.94％(57/62),which was higher than that of Group A[75.81％(47/62)],with P＜0.05.The incidence of adverse reac-tions in Group B was 8.06％(5/62),which was slightly lower than that of Group A[12.90％(8/62)],with P＞0.05.Conclusion Pralofen combined with Emadine has a good effect on the treatment of AC,which can effectively alleviate patient symptoms,improve tear film stability,improve tear index levels and inflammatory factor levels,and has fewer ad-verse reactions.It is effective and safe and is worth promoting.
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