Objective To investigate the effectiveness of triple prehabilitation in improving physical and psychological functioning and clinical outcomes in patients undergoing radical oral cancer surgery.Methods A total of eighty-four pa-tients undergoing radical resection at the First Affiliated Hospital of Bengbu Medical University were selected by random number table method to either an intervention group(n=42)or a control group(n=42)from March to November 2023.Patients in the control group received routine nursing,while those in the intervention group received triple prehabilitation intervention.Activity levels,nutritional levels,anxiety and depression,and postoperative clinical outcome indicators were compared between the two groups at baseline and post-intervention.Results In the intervention group,the 6-mi-nute walk distance(6MWD)one day preoperatively was significantly higher than on admission day,with significantly higher 6MWD and improvement rates compared to the control group(P＜0.05).The serum levels of serum prealbumin(PA),albumin(ALB)and total protein(TP)in the intervention group were increased one day preoperatively and one day before discharge,all indexes were higher than those in the control group(P＜0.05).Hospital anxiety and depression scale(HADS)scores in both intervention and control groups increased from admission to one day preoperatively,but were lower in the intervention group compared to the control group,and significantly lower in the intervention group one day before discharge(P＜0.05).The intervention group also experienced shorter times to extubation pots-tracheotomy,first ambulation,first oral intake,lower incidence of complications,and shorter total hospital stay compared to the control group(P＜0.05).Conclusion The application of triple prehabilitation in oral cancer radical surgery patients can im-prove preoperative physical function and perioperative nutritional status,relieve anxiety and depression,promote postop-erative recovery,and optimize clinical outcomes to a significant extent.
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