Objective To investigate the effect of personalized comprehensive nursing on endoscopic mucosal resection(EMR)in patients with colonic polyps and analyze surgical-related indicators,postoperative pain,negative emotions,postoperative complications rate,and nursing satisfaction during hospitalization.Methods A total of 118 colonic polyps patients who underwent EMR at Lishui Central Hospital from September 2021 to November 2022 were selected and divid-ed into a control group(59 cases)and an observation group(59 cases)using the digital table method.The control group received the routine procedure,while the observation group received personalized comprehensive nursing.Surgical-related indicators,postoperative pain,negative emotions,postoperative complications rate,and nursing satisfaction were com-pared between the two groups.Results Compared with the control group,the observation group showed significantly re-duced intraoperative blood loss,time to first exhaust,time to first defecation,time to first activity out of bed,and hospi-talization time(P<0.05).After nursing,the visual analogue scale(VAS)score[(1.96±0.80)points vs.(3.36±1.37)points],self-rating anxiety scale(SAS)score[(32.61±3.75)points vs.(36.98±4.70)points],and self-rat-ing depression scale(SDS)score[(30.20±4.23)points vs.(34.50±2.69)points]in the observation group were low-er than those in the control group(P<0.05).Moreover,the observation group had a significantly lower postoperative complications rate[10.2%(6/59)vs.27.1%(16/59)]and higher nursing satisfaction rate[89.8%(53/59)vs.74.6%(44/59)]compared to the control group(P<0.05).Conclusion Personalized comprehensive nursing model can shorten the postoperative recovery time,reduce postoperative pain,promote emotional recovery,reduce postoperative complications,and enhance nursing satisfaction in colonic polyp patients undergoing EMR.