Objective The present study aims to compare and analyze the clinical efficacy of donepezil monotherapy ver-sus the combination therapy of donepezil and calcitriol in treating mild cognitive impairment(MCI),with the intention of providing a scientific basis and guidance for therapeutic regimens for MCI patients.Methods A total of 172 MCI pa-tients were selected from Huzhou Central Hospital from February 2020 to July 2022 and divided into a control group(74 cases)and an observation group(98 cases)by random number table method.The control group was given donepezil(5 mg/d)and placebo(saline capsule,1 pill/d)on the basis of non-drug treatment.The observation group was given done-pezil(5 mg/d)and calcitriol(0.25 μg/d).Mini-mental state examination(MMSE)scale,Montreal cognitive assess-ment(MoCA)scale,and functional activity questionnaire(FAQ)were compared between the two groups at the 6th month and 12th month.Results There were statistically significant improvements in MMSE,MoCA,and FAQ in both groups at the 6th month and 12th month compared to baseline(P＜0.05).With the 12th month as the main endpoint,the MMSE of the observation group was better than that of the control group(P＜0.05),and there were no significant differences in MoCA and FAQ between the two groups(P＞0.05);The incidence of adverse drug reactions in the control group and observation group was 1.35％(1/74)and 1.02％(1/98),respectively,and the proportion of poor medica-tion adherence was 12.16％(9/74)and 11.22％(11/98),respectively.There were no statistically significant between the two groups(P=0.999,0.849).Conclusion Donepezil or combined administration of donepezil+calcitriol based on non-drug intervention has a favorable impact on MCI patients,but the drug combination scheme does not exhibit evi-dent advantages.
维普
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