Improvement of aspirin preparation experiment and exploration of green synthetic method
The preparation of aspirin is one of the classic contents of organic chemistry experiment teaching.In most organic chemistry experiment textbooks,concentrated sulfuric acid serves as the cat-alyst.However,concentrated sulfuric acid is highly oxidizing and corrosive,which is not conducive to the operation of students.Meanwhile,the reaction raw material acetic anhydride is used as a solvent,and the excess acetic anhydride is removed by hydrolysis after the experiment,resulting in waste of re-agents and environmental pollution.Based on the concept of green chemistry,the non-toxic,green and reusable Amberlystⓒ15 ion exchange resin was selected as the catalyst for this experiment,which could reduce the amount of acetic anhydride.After optimizing the conditions,aspirin was synthesized in 85%yield at room temperature.As a consequence,the experiment realized the improvement of as-pirin preparation experiment and explored the green synthetic method of aspirin at the same time.This experiment can not only enhance students' comprehensive experimental ability and environmental awareness,but also stimulate their innovative thinking and interest in scientific research.
aspirinAmberlystⓒ15 ion exchange resinexperimental improvementgreen synthetic method
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