Objective To evaluate the clinical efficacy of a novel self-fabricated windowed transparent conduit in facilitating minimally invasive single-incision surgery for carpal tunnel syndrome.Methods From June 2021 to July 2023,our department treated 21 patients suffering from carpal tunnel syndrome using this innovative technique.The functional status and severity of symptoms were assessed using the Boston Carpal Tunnel Questionnaire-Functional Status Scale(BCTQ-FS)and Symptom Severity Scale(BCTQ-SS),respectively.Results All the surgical procedures were completed expediently within 10 minutes,with a minimal blood loss of approximately 3ml,and no intraoperative damage to nerves,blood vessels,or tendons occurred.All 21 patients were followed up for a period ranging from 6 to 12 months,during which both BCTQ-FS and BCTQ-SS scores significantly decreased(P<0.05).One patient exhibited persistent thenar and hypothenar muscle atrophy due to prolonged nerve compression,which resulted in less noticeable postoperative muscle atrophy improvement.Clinical outcomes at the final follow-up were rated as excellent in 19 cases,good in 1 case,and fair in 1 case,marking an effectiveness rate of 95.2%.Conclusion The self-made windowed transparent conduit for minimally invasive single-incision surgery offers a promising approach to carpal tunnel syndrome treatment,characterized by minimal invasiveness and significant therapeutic outcomes.