Epidemiological characteristics of respiratory syncytial virus infection among hospitalized children in a certain grade-A tertiary general hospital in Hunan Province before and after prevention and control of the SARS-CoV-2 epidemic
Objective To explore the epidemiological characteristics of respiratory syncytial virus(RSV)infection in hospitalized children before and after prevention and control of the SARS-CoV-2 epidemic.Methods We collected nasopharyngeal swab specimens from clinically suspected respiratory tract infection children admitted to Children's Medical Center of Hunan Provincial People's Hospital from January 1,2018 to December 31,2021,and seven common respiratory viruses were detected by direct immunofluorescence method.The detection data were statistically analyzed.The date December 31,2019 was used as the time point to divide the data into data before and after prevention and control of the SARS-CoV-2 epidemic.Results The first pathogen detected was respiratory syncytial virus(11.63％),followed by parainfluenza virus 3(3.90％)and adenovirus(2.32％).There was a statistically significant difference in the positive detection rate of RSV before and after prevention and control of the SARS-CoV-2 epidemic(10.27％vs.13.80％,x2=94.211,P＜0.001).The younger the age,the higher the detection rate of RSV,moreover,the age percentages of hospitalized children before and after prevention and control of the SARS-CoV-2 epidemic had changed.The detection rate of RSV was 12.01％in male children and 11.05％in female ones,and there was a difference in the RSV infection rate between the genders(x2=7.141,P＜0.01),but no difference was found in the percentage(x2=0.085,P＞0.05).There was a clear seasonality in the RSV detection rate before the prevention and control,with a trough of RSV detection rate in May-October,a clear upward trend from November,and peaks in December,January and February.The trough of RSV detection rate after the prevention and control was advanced to March-August 2020,but a small peak of continuous fluctuation occurred from October 2020 to July 2021,and its seasonality was disrupted.Conclusion The RSV infection was reduced during the initial period of prevention and control of the SARS-CoV-2 epidemic,but with the relaxation of prevention and control policies,RSV resurfaced with a trend of year-round epidemic.Testing for RSV should be enhanced throughout the year so as to control the source of infection as early as possible.
childrenrespiratory syncytial virusepidemic characteristicSARS-CoV-2epidemic prevention and control
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