目的 明确高血清脂蛋白(a)水平对急性缺血性脑卒中患者预后的影响.方法 采用主题词结合自由词方式,检索了 PubMed、Web of Science、中国知网、万方数据知识服务平台等数据库,范围是建库以来至2022年4月有关脂蛋白(a)水平与急性缺血性脑卒中患者预后相关的文献,提取内容包括作者、出版年份、研究对象、研究类型、主要结局指标和结论.结果 纳人文献15篇,从功能预后、复发事件、认知障碍和深静脉血栓形成等方面进行评价.高血清脂蛋白(a)水平的急性缺血性脑卒中患者的功能障碍预后更差,复发风险更高,认知功能损害更重,深静脉血栓形成发病率更高.结论 和正常血清脂蛋白(a)水平的急性缺血性脑卒中患者相比,高血清脂蛋白(a)水平的急性缺血性脑卒中患者预后相对较差.
A systematic review on the effect of high serum lipoprotein(a)levels on the prognoses of patients with acute ischemic stroke
Objective To clarify the impact of high serum lipoprotein(a)levels on the prognoses of patients with acute ischemic stroke.Methods We searched PubMed,Web of Science,CNKI and Wan-fang database to identify the literatures regarding lipoprotein(a)levels and prognoses of patients with acute ischemic stroke from the establishment of the databases to April 2022 by using subject words combined with free words,and the extracts included authors,year of publication,study population,study types,key outcome indicators and conclusions.Results Fifteen relevant papers were finally enrolled into this study,and then evaluated in terms of functional prognosis,recurrent event,cognitive impairment and deep vein thrombosis.Acute ischemic stroke patients with high serum lipoprotein(a)levels had a poor prognosis in functional impairment,a high risk of recurrence,severer cognitive impairment and a high incidence of deep vein thrombosis.Conclusion Acute ischemic stroke patients with high serum lipoprotein(a)levels have poor prognoses compared with those with the normal level of serum lipoprotein(a).
万方数据
维普
