Liver fibrosis is a pathological repair response to chronic liver disease,amd is characterized by the overaccumulation and reorganization of extracellular matrix.Liver biopsy is the gold standard for liver fibrosis determination.The use of non-invasive serum markers of liver fibrosis is particularly important due to the various limitations of this method,including patient injury and the risk of sampling errors.With intensive researches,some emerging biological markers are providing new clues to early predicting the severity of liver fibrosis in the clinical setting,assessing the effectiveness of treatment,improving the prognosis and finding out new therapeutic targets.
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