Review on genes related to smoking population and occurrence and development of lung cancer
The pathogenesis of lung cancer is related to the malignant transformation of lung tissue cells induced by carcinogens in cigarette smoke,but the individuals'dissimilar abilities to metabolize these carcinogens make the prevalence of lung cancer different in smoking population,and human genetic polymorphism plays a key role in the carcinogenic effect of cigarette carcinogens.Studies have shown that genes related to smoking population are significantly associated with lung cancer susceptibility.Gene mutations like CYP450,GSTs,ERCC1,CHRNA5,EGFR and FHIT can increase the risk of lung cancer in smoking population.By clarifying the role mechanism of involvement of relevant genes in the occurrence and development of lung cancer and their impacts on chemotherapy drug resistance,it will help guide clinical rational drug use.This study reviews the relationships of genes related to smoking population with the occurrence and development of lung cancer so as to provide new ideas for lung cancer prevention and treatment in smoking population.
万方数据
维普
