目的 探讨预后营养指数(prognostic nutritional index,PNI)与脑卒中患者抑郁风险的关系,为脑卒中患者预后管理提供参考.方法 选取美国国家健康和营养调查(National Health and Nutrition Examination Survey,NHANES)数据库2017-2020年收录的脑卒中后幸存者作为研究对象,评估其抑郁情况并计算PNI,采用多因素logistic回归分析PNI对脑卒中患者抑郁风险的影响.结果 共纳入443例研究对象,包括男性220例,女性223例,平均年龄(65.22±12.44)岁,共检出抑郁95例(21.44％).脑卒中后抑郁患者PNI指数为(47.23±7.01)分,低于非抑郁患者的(49.59±5.51)分,组间差异有统计学意义(P＜0.05).多因素logistic回归结果显示,在调整性别、年龄、教育水平、婚姻状态、吸烟史等混杂因素后,PNI评分升高对脑卒中后抑郁有明显的保护作用(OR=0.929,95％CI:0.892～0.968,P＜0.05).结论 PN1评分升高对降低脑卒中患者抑郁风险具有一定作用,维持良好的营养状态和免疫功能对于预防脑卒中患者抑郁、改善预后效果具有重要意义.
Effect of prognostic nutritional index on the risk of depression in stroke patients:a cross-sectional survey based on NHANES,2017-2020
Objective To explore the relationship between prognostic nutritional index(PNI)and the risk of depression in stroke patients so as to provide references for prognostic management of patients with stroke.Methods Stroke survivors selected from the National Health and Nutrition Examination Survey(NHANES)database from 2017 to 2020 served as the research subjects.Their depression status was assessed,and PNI was calculated.Multivariate logistic regression was used to analyze the effect of PNI on the risk of depression in the stroke patients.Results A total of 443 subjects were enrolled into this survey,including 220 males and 223 females,with the average age of(65.22±12.44)years.A total of 95(21.44％)cases of depression were detected.The PNI score was lower in post-stroke depression patients than in non-depressed patients((47.23±7.01)vs.(49.59±5.51)),showing a statistically significant difference between the two groups(P＜0.05).The results of multivariate logistic regression displayed that after adjusting for confounding factors such as gender,age,education level,marital status and smoking history,the increase of PNI score had a significantly protective effect on post-stroke depression(OR=0.929,95％CI:0.892-0.968,P＜0.05).Conclusion The increase of PNI score has a certain effect on reducing the risk of depression in the stroke patients.It is of great significance for preventing depression and improving prognosis in the stroke patients to maintain better nutritional status and immune function.
prognostic nutritional indexstrokedepressionthe National Health and Nutrition Examination Survey database
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