Current status and hotspot analysis of research on osteoporosis and intestinal flora based on Web of Science database
Objective To analyze the literatures related to osteoporosis and intestinal flora research based on Web of Science database,to clarify its research hotspots and trends,and to provide references for related research in future.Methods The Web of Science Core Collection database was searched by subject term fields.The time was set from the establishment of the database to 2022,and the search was completed on May 9,2023.The bibliometric method and CiteSpace software were employed to statistically analyze the literature characteristics such as country/region,institution,journal and keywords.Results A total of 376 valid papers were obtained,including 247 papers and 129 reviews.The study started in 1998,and the overall number of studies kept growing,especially the most significant increase in the number of literatures after 2019.The research countries were mainly distributed in Asia,the United States and Europe,and the research institutions were mainly universities.The countries with the top 10 journals with published literatures were the United States and Switzerland.Nutrients(16 articles,4.26％)published the largest number of articles,and Bone had the highest average citation frequency,with 36.17 times.Four of the top 10 cited studies were related to the role of probiotics in the prevention and treatment of postmenopausal bone loss,with the title of"sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics"being cited the most frequently and the number of citations being 96.Hot topics of research included the correlation between osteoporosis and gut flora(keywords:mineral density,health,bone density,bone loss,etc.)and the focus on potential targets of gut flora to prevent osteoporosis(keywords:gut permeability,gut-bone axis,short-chain fatty acids,etc.).The research trend was hip fracture.Conclusion The attention of osteoporosis and intestinal flora research has continued to increase during the past 20 years.It is recommended that multi-center and large-scale clinical studies should be conducted to validate and promote the relevant intestinal flora regulatory mechanisms and therapeutic targets.
osteoporosisintestinal floraWeb of Sciencevisual analysis
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