由于抗逆转录病毒药物的规范使用,艾滋病患者的生存期明显延长,与年龄相关的心血管疾病日渐增多.高血压作为最常见的心血管疾病,在HIV携带者(people living with HIV,PLWH)中的发病率明显高于一般人群.对于PLWH来说,除了存在传统的高血压的相关因素外,HIV本身刺激、HIV感染后免疫激活、肠道菌群易位和抗病毒治疗药物不良反应等,均可以驱动炎症,导致血管内皮细胞损伤,促进高血压的发生.本研究简要综述了 HIV感染相关的因素驱动炎症从而参与PLWH发生高血压的机制,旨在为PLWH高血压的治疗提供新的方向.
Research progress of inflammation in hypertension amongst people living with HIV
The survival period of AIDS patients has been significantly prolonged because of the standardized use of antiretroviral drugs,and the age-related cardiovascular diseases are increasing accordingly.As the most common cardiovascular disease,the incidence rate of hypertension is significantly higher in people living with HIV(PLWH)than in the general population.As for PLWH,not only traditional related factors that affect hypertension but also HIV stimulation,immune activation after HIV infection,translocation of intestinal flora,and adverse reactions to antiretroviral drugs can drive inflammation,cause vascular endothelial cell damage,and promote the occurrence of hypertension.This study briefly reviews the mechanisms by which factors related to HIV infection drive inflammation and participate in the occurrence of hypertension in PLWH,with the aim of providing a new direction for the treatment of hypertension in PLWH.
people living with HIVhypertensioninflammationimmune activation
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