Research progress on the characteristics of antibiotic resistance in probiotics
Owing to the increasing use of antibiotics in human beings and animals at present,the problem of microbial drug resistance has developed into one of the major global public health problems.As one of the largest producers and consumers of antibiotics,the transmission of drug-resistant genes is a cause for concern.Given the global attention towards probiotics,it is necessary to pay close attention to the transmission of drug-resistant genes that may be brought about by probiotics while fully affirming their health efficacy.Studies have shown that drug-resistant genes presented in probiotics can be transmitted to pathogenic bacteria in the human gut via horizontal gene transfer and lead to the development of drug-resistant infections.Hence it is imperative to further explore the mechanism of drug resistance and transmission characteristics of drug resistance genes in probiotics.In this review,we provide an overview of the composition and transmission mechanism of drug-resistant genome in human intestinal flora.Furthermore,we review the mechanism of drug resistance in probiotics and the development characteristics of drug resistance in probiotics driven by drug-resistant genes,and summarize the current research bottleneck of mechanism of drug resistance in probiotics and the safety evaluation of probiotics for future research.
probioticsdrug-resistant genedrug resistance mechanismhorizontal transfer
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