Association of blood thallium with metabolic syndrome among senior citizens in an urban community in Hefei City
Objective To explore the association between blood thallium(Tl)and metabolic syndrome(MS)among urban community-dwelling senior citizens.Methods From March to October 2022,senior citizens aged 60 years and above were selected from a community in Hefei City,Anhui Province to conduct a questionnaire survey,physical examination and laboratory tests.Diagnosis of MS was based on the standards of Adult Treatment Panel Ⅲ(ATP Ⅲ),USA.The concentrations of Tl in whole blood were measured by inductively coupled plasma-mass spectrometer(ICP-MS),and then divided into four groups.Univariate and multivariate logistic regression models were used to analyze the correlation between blood Tl and MS in the senior citizens,and restricted cubic spline(RCS)was employed to further analyze the dose-response relationship between them.Results A total of 1,008 senior citizens were enrolled in this study,with the mean age of(7 1.87±6.46)years.The prevalence rate of MS was 43.95％(443/1,008).The detection rate of blood Tl was 92.26％,and the median concentration 0.083 μg/L.After adjustment for gender,age,educational background,occupation,marital status,status of smoking,alcohol consumption,physical exercise,diet,salt intake,oil intake and sugar intake,hypertension,diabetes,and body mass index(BMI),there was a significant positive correlation between blood Tl and MS(ORQ2 vs.Q1=1.787,95％CI:1.057-3.021;ORQ3 vs.Q1=2.120,95％CI:1.236-3.626;ORQ4 vs.Q1=2.046,95％CI:1.219-3.438).The restricted cubic spline curve showed a non-linear dose-response relationship between blood Tl and MS:the risk of MS significantly increased and then gradually decreased with the increase in blood Tl concentration.Conclusion Exposure to Tl may be an independent risk factor for MS in the senior citizens.Given the widespread application of Tl in daily life,industry and medical products,its etiological and public health implications for the occurrence of MS are worthy of attention.
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