Values of high-risk pregnancy history combined with serum placental growth factor and 25-hydroxy vitamin D in predicting pre-eclampsia
Objective To explore the values of high-risk pregnancy history combined with placental growth factor(PLGF)and 25-hydroxy vitamin D(25-OH-VD)in predicting pre-eclampsia(PE)in the first trimester.Methods We retrospectively selected 362 pregnant women who underwent prenatal examination at 11+0-13+6 weeks of gestation and delivered in Hunan Provincial Maternal and Child Health Hospital from January 2019 to December 2021,and then they were enrolled in the study.The correlations of high-risk pregnancy history,serum PLGF and 25-OH-VD with the occurrence of PE were analyzed,and their predictive values for PE were evaluated.Results A total of 362 pregnant women were enrolled in the study,106(29.28％)of whom developed PE.PE was more common in pregnant women with high-risk pregnancy history,PLGF≤39 pg/ml and 25-OH-VD＜30 ng/ml,and the differences were statistically significant(all P＜0.001).Logistic regression analysis displayed that pregnant women with high-risk pregnancy history(OR=3.219,95％CI:2.045-5.066),PLGF≤39 pg/ml(OR=2.621,95％CI:1.635-4.200)and 25-OH-VD＜30 ng/ml(OR=13.417,95％C/:8.173-22.024,P=0.000)had a higher risk of occurrence of PE compared with those without high-risk pregnancy history,with PLGF＞39 pg/ml and 25-OH-VD ≥30 ng/ml.The results of receiver operator characteristic(ROC)curve revealed that high-risk pregnancy history,PLGF and 25-OH-VD levels all had predictive efficacy on the occurrence of PE,and the predictive efficacy of combined detection of the above-mentioned three indexes was higher than that of the single index detection,with the sensitivity being 81.8％,the specificity being 69.7％and the Youden index being 0.515.Conclusion High-risk pregnancy history,PLGF and 25-OH-VD all have predictive values for the onset of PE,and the predictive value of the combined detection is superior to any single index detection.
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