Evaluation on toxicological safety of egg yolk phospholipids
Objective To study the edible safety of egg yolk phospholipids,and to provide a scientific basis for the high-efficiency development and utilization of the resources.Methods According to the National Standard for Food Safety,we conducted an evaluation on toxicological tests of safety of egg yolk phospholipids,including acute oral toxicity test,three genetic toxicity tests and 90-day oral toxicity test.Results Acute oral toxicity test showed that egg yolk phospholipid was actually non-toxic grade,and three genetic toxicity tests displayed negative results.During the 90-day oral toxicity test,SD rats were in good condition and did not die.No statistically significant differences were found in body weight,food intake amount,food utilization rate,body weight gain during the tests,total food intake amount,total food utilization rate,blood routine,blood biochemical and coagulation indicators in female and male rats between each dose group and each control group(P＞0.05).There were no abnormal changes related to tested substances in urine routine,ocular examination,gross anatomy and histopathology.The 90-day oral toxicity test revealed that egg yolk phospholipids did not have a toxic effect on rats.The dose of no observed adverse effect level in the 90-day oral toxicity test was 8.03 g/kg·bw for male rats and 10.26 g/kg·bw for female ones.Conclusion Under the experimental conditions,egg yolk phospholipids show no acute toxicity,genetic toxicity and sub-chronic toxicity,and thus have a high edible safety.
egg yolk phospholipidsafety evaluation testtoxicity study
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