Correlation between exposure to perfluoroalkyl substances and stroke patients'depression:a cross-sectional study based on NHANES
Objective To explore the potential relationship between exposure to perfluoroalkyl substances(PFAS)and the risk of post-stroke depression,and to provide a basis for post-stroke depression prevention and management.Methods Statistical data during 2011-2020 based on the US National Health and Nutrition Examination Survey(NHANES)database were used to select 3,411 post-stroke survivors as the study subjects.We collected four types of PFAS,namely,perfluorooctanoic acid(PFOA),perfluorooctane sulfonates(PFOS),perfluorohexane sulfonate(PFHxS)and perfluorononanoic acid(PFNA).Multifactor logistic regression analysis was performed to identify the correlation between PFAS and post-stroke depression.Results Six hundred and sixteen patients with stroke were finally enrolled in the study,and the prevalence rate of post-stroke depression was 16.72％.The levels of PFOA,PFOS,PFHxS and PFNA exposure in the depression group were lower than those in the non-depression group,with statistically significant differences(Z=-4.901--3.488,P＜0.05).The results of multifactor logistic regression analysis revealed that after adjusting for demographic characteristics like gender,age,race and body mass index as well as covariates like educational background,combined hypertension,diabetes,history of alcohol consumption,marital status,family income level and history of smoking,the higher the exposure levels of PFOA(OR=0.573,95％CI:0.428-0.769),PFOS(OR=0.832,95％CI:0.759-0.912),PFHxS(OR=0.710,95％CI:0.559-0.901)and PFNA(OR=0.210,95％CI:0.098-0.452),the lower the prevalence rate of depression in the post-stroke survivors(all P＜0.05).Conclusion Exposure to PFOA,PFOS,PFHxS and PFNA is negatively associated with the risk of developing post-stroke depression.Further prospective cohort study is needed to validate these findings.
perfluoroalkyl substancestrokedepressioncross-sectional study
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NSTL
万方数据
