Epidemic characteristics of hand,foot and mouth disease and the effect of EV71 vaccination in Kunshan City,2008-2022
Objective To understand the incidence situation and vaccination effect of hand,foot and mouth disease(HFMD)since it was brought into legal management,and to provide a basis for formulating effective prevention and control strategies.Methods Descriptive epidemiological methods were used to analyze the data regarding HFMD incidence,etiology monitoring and vaccination in Kunshan City from 2008 to 2022.Results A total of 25,759 HFMD cases were cumulatively reported in Kunshan City from 2008 to 2022,and the average annual reported incidence rate was 70.80/100,000,which was lower than the national level of the same period.The proportion of severe cases decreased significantly.The incidence peak occurred every other year.Two incidence peaks were observed each year,one in May-July,and another in September-November.The incidence rate was higher in males than in females.The age-at-onset in HFMD was concentrated in children under 5 years old,and most of the cases were children below the age of 3 years.The incidence rate was higher in townships than in urban areas.The main pathogens were EVG and CoxA16 in 2014-2016,and CoxA6 was predominant in 2017-2022.After the wide use of EV71 vaccine,the proportion of severe cases was lower than that before the promotion(P＜0.001).Conclusion HFMD in Kunshan City during 2008-2022 showed a trend of high incidence,and EV71 vaccine had better effect on preventing severe HFMD.It is necessary to actively develop a multivalent vaccine and improve the vaccination rate,strengthen health education and intervention,and take comprehensive measures to reduce the incidence of HFMD.
hand,foot and mouth diseaseepidemic characteristicetiology surveillanceEV71 vaccineprevention and control strategy
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