Research progress on the development of integrated detection methods for human papillomavirus in cervical cancer
Human papillomavirus(HPV)is a common genital tract infection virus,which is divided into high-risk and low-risk types according to its carcinogenicity.Persistent HPV infection with high-risk types is the main cause of cervical cancer.The integration of the HPV viral genome into the human(host)genome is thought to be the molecular basis of persistent HPV infection as well as a key step in the development of cervical cancer.The HPV integrated detection method began with the Southern blot in 1987,and then a series of PCR-based classical methods appeared.With the development of high-throughput sequencing technology at present,HPV integrated detection methods have also been further developed.However,clinical transformation has not yet been realized due to the limitations of the current technology.This study reviews the current relevant methods for HPV integration detection.
human papillomavirusvirus integrationcervical cancerhigh-throughput sequencing technology
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NSTL
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