Epidemic characteristics of norovirus infection among children with sporadic diarrhea in Hangzhou City,2020-2022
Objective To analyze the status of norovirus infection,genotype changes and other epidemic characteristics among children with sporadic diarrhea in Hangzhou City from 2020 to 2022.Methods We collected 655 stool specimens and epidemiological data from children with sporadic diarrhea in the sentinel hospital in Hangzhou City from 2020 to 2022.Norovirus RNA was detected by quantitative real-time polymerase chain reaction(PCR),and the positive samples were sequenced and genotyped.The epidemic characteristics of norovirus infection were descriptively analyzed.Results Among the 655 stool specimens from children with sporadic diarrhea,the overall positive detection rate of norovirus was 21.68％(142/655).There were statistically significant differences in the positive detection rates among different age groups(x2=13.792,P=0.003),among which the positive detection rate was found to be the highest in children aged 13-24 months(34.17％,41/120).The peak incidence of norovirus infection was observed in spring and autumn,and the average positive detection rate was found to be the highest in October(50.53％,48/95).82 positive specimens were successfully sequenced,including 6 recombinant genotypes,GⅡ.3[P12](41.46％,34/82),GⅡ.4[Pe](43.90％,36/82),GⅡ.4 Sydney_2012[Pe](7.32％,6/82),GⅡ.17[P17](4.88％,4/82),GⅡ.6[P7](1.22％,1/82)and GⅡ.2[P16](1.22％,1/82).GⅡ.3[P12]was the dominant strain in 2020,and GⅡ.4[Pe]had replaced GⅡ.3[P12]as the new dominant strain since 2021.Conclusion The high incidence season of norovirus infection is in spring and autumn,with the peak in October.The positive detection rate of norovirus in children aged 13-24 months is the highest,and the dominated genotypes of norovirus are GⅡ.4[Pe]and GⅡ.3[P12].
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