Objective To investigate the relationship between red cell distribution width(RDW),β2-microglobulin(MG),and maintenance hemodialysis(MHD),as well as cognitive impairment(CI)in MHD patients.Methods Clinical and laboratory data of 195 MHD patients in blood purification center of the Third Hospital of Shanxi Medical University from January 2022 to June 2022 were collected and screened with simple mental state checklist.Logistic regression was used to analyze the risk factors for CI in MHD patients,and the receiver operating curve(ROC curve)was used to examine the predictive value of RDW and β,-MG for CI in MHD patients.Results In our institution,there were 71 cases of CI among 195 MHD patients,with a prevalence rate of 36.4％.RDW and β2-MG were found to be independent risk variables for CI in MHD patients using logistic regression analysis.RDW predicted CI in MHD with a sensitivity of 80.3％,specificity of 83.1％,and area under the curve 95％CI was 0.856(0.803,0.909),(P＜0.05).The sensitivity and specificity of β2-MG in predicting CI in MHD patients were 87.3％and 78.2％,respectively,and the area under the curve 95％CI was 0.872(0.821,0.922)(P＜0.05).RDW in conjunction with β2-MG was projected to have a sensitivity of 85.9％,specificity of 88％,and area under the curve 95％ CI was 0.949(0.922,0.975)(P＜0.05).Conclusion High RDW and β2-MG have certain predictive value for cognitive impairment in MHD patients,and the combined detection of RDW and β2-MG has higher predictive value for cognitive impairment in MHD patients.
关键词
血液透析,维持性/认知障碍/红细胞分布宽度/β2-微球蛋白
Key words
Hemodialysis,maintenance/Cognitive impairment/Red blood cell distribution width/β2-microglobulin
万方数据