Objective To compare the inflammatory markers,coagulation function,and disease outcomes of COVID-19 patients with or without type 2 diabetes and discuss the inflammatory characteristics and their interaction in COVID-19 patients with type 2 diabetes.Methods A retrospective study was conducted on a total of 311 hospitalized patients with mild or moderate COVID-19 at Taiyuan People's Hospital from December 2022 to April 2023.The study included 115 patients in the type 2 diabetes group(T2DM group)and a matched control group consisting of 196 non-diabetic patients who received medical treatment during the same period.Blood cell analysis,inflammation index,coagulation function,other laboratory indicators as well as nucleic acid negative time were compared between the two groups.Clinical data such as hospital stay and use of hormones were also analyzed.Results The lymphocyte count was lower while neutrophil count and C-reactive protein levels were higher in the diabetic group compared to the control group(P＜0.05).D-dimer levels were significantly increased in the diabetic group(P＜0.05).The duration of negative nucleic acid test results and hospital stay were longer in the diabetic group along with a higher usage rate of hormones.Conclusion Diabetes is a high-risk factor for COVID-19 infection which further complicates blood glucose regulation in diabetic patients.The combination of diabetes and COVID-19 increases susceptibility to an"inflammatory storm,"leading to worse prognosis including prolonged hospital stays and increased risk of death.
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