Objective To This study aims to investigate the potential role of thrombelastogram(TEG)in guiding the treatment of recurrent spontaneous abortion(RSA).Methods Eighty patients with RSA admitted to the Department of Reproductive Medicine our hospital from July 2021 to July 2023 were selected as the observation group,and were randomly divided into conventional treatment group(n=40)and combined treatment group(n=40).The conventional treatment group was treated with low dose aspirin tablets after confirming intrauterine pregnancy,which was continued until 20 weeks of pregnancy.In addition,the combined treatment group also received low molecular weight heparin calcium injection starting from week 12 of pregnancy.The five items of coagulation function for evaluating improvement of coagulation,TEG parameters,and blood routine indexes before and after treatment were compared between the two groups.Meanwhile,a control group consisting of 80 women in childbearing age from our hospital was screened,and their five items of coagulation function,TEG parameters,and blood routine indexes before treatment were compared with those in the observation group.Results Before treatment initiation,both subgroups within the observation group(conventional treatment group and combined treatment group)showed increased D-dimer and FIB levels while decreased APTT levels when compared with the control group(the changes in FIB and APTT did not exceed their reference intervals).Moreover,there was a statistically significant decrease in R value for TEG parameters along with an increase in MA and CI values(P<0.05),whereas no significant differences were observed regarding blood routine indexes(P＞0.05).Furthermore,prior to therapy initiation within the observation group comparing different treatments methods showed no statistically significant differences among all five items of coagulation function TEG parameters,and blood routine indexes(P＞0.05).After treatment,D-D dimer decreased,the R value of TEG parameters increased along with an decreased in MA and CI values in the two groups,and the improvement effect was more obvious in the combined treatment group.The differences were statistically significant(P<0.05),and the changes of APTT before and after treatment between the two groups were also statistically significant(P<0.05),but the changes did not exceed the reference interval.The incidence of abortion was 7.5%(3/40)in the combined treatment group and 15.0%(6/40)in the conventional group,which was lower than that in the conventional treatment.Conclusion Through the analysis of TEG,it can more sensitively reflect whether RSA patients are in pre-thrombotic state during non-pregnancy,and can be more effective in guiding drug use.The abortion rate of RSA patients can be reduced by low-dose aspirin combined with low molecular weight heparin.
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