Objective To explore the correlation between the severity of ulcerative colitis(UC)and serum insulin-like growth factor 1(IGF-1),C-reactive protein(CRP)and systemic immune inflammatory index(SII).Methods A retrospective analysis was conducted on the clinical data of 68 UC patients who received treatment in our hospital from August 2021 to April 2023,and they were assigned to the observation group.34 healthy individuals who underwent physical examination during the same period were selected as the control group.The serum levels of IGF-1,CRP,and SII between the two groups of study subjects,and in patients with UC of different severity were compared respectively.We Analyzed the correlation between three indicators and whether patients have UC,and the correlation between the severity of disease in UC patients and three indicators.Results The serum IGF-1 level in the observation group was lower than that in the control group,while the serum CRP level and SII were higher than those in the control group(P<0.05).The serum IGF-1 levels in severe UC patients were significantly lower than those in moderate and mild patients,while the serum CRP levels and SII were significantly higher than those in moderate and mild patients(P<0.05).The serum IGF-1 level in moderate UC patients was significantly lower than that in mild UC patients,while the serum CRP level and SII were significantly higher than those in mild UC patients(P<0.05).Serum IGF-1,serum CRP,and SII are all correlated with the occurrence of UC in patients(P<0.05).The severity of UC patients is positively correlated with CRP and SII,and negatively correlated with serum IGF-1(P<0.05).Conclusion Serum IGF-1,CRP,and SII are closely related to the occurrence and development of UC,and can be used as auxiliary indicators to determine the severity of UC.
Colitis,ulcerativeSeverity of illness indexInsulin-like growth factor 1C-reactive protein
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