Objective To explore the predictive efficacy of plasma adrenomedullin(ADM)and nitric oxide(NO)levels on apnea of prematurity(AOP)in infants.Methods A retrospective analysis was conducted on the clinical data of 80 premature infants with gestational age≤32 weeks admitted to our hospital from January 2022 to August 2023.The infants were divided into AOP group(n=51)and non AOP group(n=29)based on whether they had AOP within 7 days of birth.The clinical data of the two groups were compared to evaluate the predictive efficacy of plasma ADM and NO levels on AOP in children.Results The gestational age and body mass of the AOP group were lower than those of the non AOP group(all P<0.05),ADM levels were higher than those of the non AOP group(P<0.05),and NO levels were lower than those of the non AOP group(P<0.05).Multivariate logistic regression analysis showed that gestational age,body mass,ADM,and NO levels were all risk factors for the occurrence of AOP(P<0.05).The receiver operating characteristic curve(ROC)analysis showed that the cutoff value corresponding to the maximum ADM Jordan index(0.730)was 2 278.50 pmol/L,and the area under the curve was 0.854.The sensitivity and specificity of predicting AOP were 90.2%and 82.8%,respectively.The truncation value corresponding to the maximum NO Jordan index(0.429)is 71.99 μmol/L,with an area under the curve of 0.757,the sensitivity and specificity for predicting AOP were 84.3%and 58.6%,respectively;When combined,the predicted AUC of AOP was 0.862,with sensitivity and specificity of 88.2%and 82.8%,respectively.Conclusion Plasma ADM and NO levels are risk factors for the occurrence of premature apnea,and have high predictive value for the occurrence of premature apnea.
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